Orexin A and orexin receptor 1 axonal traffic in dorsal roots at the CNS/PNS interface

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Orexin A and orexin receptor 1 axonal traffic in dorsal roots at the CNS/PNS interface

Hypothalamic orexin/hypocretin neurons send long axonal projections through the dorsal spinal cord in lamina I-II of the dorsal horn (DH) at the interface with the peripheral nervous system (PNS). We show that in the DH OXA fibers colocalize with substance P (SP) positive afferents of dorsal root ganglia (DRG) neurons known to mediate sensory processing. Further, OR1 is expressed in p75(NTR) an...

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ژورنال

عنوان ژورنال: Frontiers in Neuroscience

سال: 2014

ISSN: 1662-453X

DOI: 10.3389/fnins.2014.00020